You have edited a content file (a style, filter, or connection file), but when you try to save the file you cannot choose Save, but must choose Save As to save a copy.
The styles, filters, and connection files provided with EndNote are installed in the Styles, Filters, and Connections folders which are typically located in the EndNote program folder:
C:\Program Files\EndNote \Styles
C:\Program Files\EndNote \Filters
C:\Program Files\EndNote \Connections
However, when you create a new file, or modify one of the installed files, the file is saved in one of your personal folders. By default, your personal folders are set to:
Windows XP
C:\Documents and Settings\User Name\My Documents\EndNote\Styles
C:\Documents and Settings\User Name\My Documents\EndNote\Filters
C:\Documents and Settings\User Name\My Documents\EndNote\ConnectionsWindows Vista
C:\ Users\User Name\ Documents\EndNote\Styles
C:\ Users\User Name\Documents\EndNote\Filters
C:\ Users\User Name\ Documents\EndNote\ConnectionsWindows 7 and Windows 8
C:\ Users\User Name\ Documents\EndNote\Styles
C:\ Users\User Name\ Documents\EndNote\Filters
C:\ Users\User Name\ Documents\EndNote\Connections
When you display a list of files in EndNote, the list is compiled from both folder locations: the installation folders found in the EndNote program folder, plus your personal folders. For more information about these folder locations, and how to change them, see Folder Locations Preferences.
If you want to make a modified file available to all users, you must log in as an administrator to copy the file to the program folder location.
To make a file available to all users:
Edit the file as needed and save a copy to your personal folder.
Log off as the current user.
Log in again with administrative rights.
Copy the modified file from your personal folder to the appropriate shared folder in the EndNote program folder.